You need to change the way you patch S2D Clusters
If you’re running a Storage Spaces Direct (S2D) Cluster, you might have noticed some instability in recent months, specifically when it comes to patching and performing maintenance. Well you’re in luck because 5 days ago, Microsoft released a new KB article that helps explain why you might have seen issues.
The scenario targeted by the Microsoft article is S2D Clusters running May (KB4103723) or later patch levels, where you experience Event ID 5120 during patching or maintenance, leading to things like CSV timeouts, VM pauses, or even VM crashes.